Perforation disease refers to a serious medical condition in which a hole (perforation) develops in the wall of a hollow organ within the body—most commonly in the gastrointestinal tract, such as the stomach, small intestine, or large intestine. This perforation can allow contents of the organ (such as digestive fluids or bacteria) to leak into the abdominal cavity, leading to infection (peritonitis), inflammation, and potentially life-threatening complications.
Perforation is a surgical emergency. If not treated quickly, it can lead to severe infection, sepsis, or death. Prompt diagnosis and surgical intervention are critical for recovery.